DSM · Midwest
Nonstop into Des Moines, IA
35 U.S. airports fly here without a layover, grouped by how long you'd be in the air.
35 of 35 nonstop routes
Leave after work
Under 2 hours13 citysChicago, IL
ORD · Chicago O'Hare International Airport
52m
Many flights a day
Denver, CO
DEN · Denver International Airport
1h 17m
Many flights a day
Dallas-Fort Worth, TX
DFW · Dallas Fort Worth International Airport
1h 27m
About 4 flights a day
American
Atlanta, GA
ATL · Hartsfield Jackson Atlanta International Airport
1h 48m
About 3 flights a day
Minneapolis, MN
MSP · Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field
42m
About 3 flights a day
Detroit, MI
DTW · Detroit Metropolitan Wayne County Airport
1h 24m
About 3 flights a day
Houston, TX
IAH · George Bush Intercontinental Airport
1h 51m
About one a day
Chicago, IL
MDW · Chicago Midway International Airport
53m
About one a day
Southwest
SeasonalNonstops out of MDW →St Louis, MO
STL · St. Louis Lambert International Airport
46m
About one a day
Southwest
Nashville, TN
BNA · Nashville International Airport
1h 20m
3 flights a week
Austin, TX
AUS · Austin Bergstrom International Airport
1h 52m
2 flights a week
Allegiant
Houston, TX
HOU · William P. Hobby Airport
1h 49m
A couple of flights a week
Allegiant
SeasonalNonstops out of HOU →Valparaiso, FL
VPS · Destin-Fort Walton Beach Airport
1h 57m
A couple of flights a week
Allegiant
SeasonalNonstops out of VPS →
Easy weekend
2 to 3 hours20 citysPhoenix, AZ
PHX · Phoenix Sky Harbor International Airport
2h 21m
About 3 flights a day
Charlotte, NC
CLT · Charlotte Douglas International Airport
2h
About 2 flights a day
American
New York, NY
LGA · LaGuardia Airport
2h 32m
About 2 flights a day
Washington, DC
DCA · Ronald Reagan Washington National Airport
2h 13m
About one a day
Las Vegas, NV
LAS · Harry Reid International Airport
2h 25m
About one a day
Southwest, Allegiant
Philadelphia, PA
PHL · Philadelphia International Airport
2h 17m
About one a day
Los Angeles, CA
LAX · Los Angeles International Airport
2h 58m
6 flights a week
Regional partners: SkyWest
Orlando, FL
SFB · Orlando Sanford International Airport
2h 37m
4 flights a week
Allegiant
Pinellas Park, FL
PIE · St. Petersburg Clearwater International Airport
2h 34m
4 flights a week
Allegiant
Punta Gorda, FL
PGD · Punta Gorda Airport
2h 47m
4 flights a week
Allegiant
Mesa, AZ
AZA · Mesa Gateway Airport
2h 21m
4 flights a week
Allegiant
Santa Ana, CA
SNA · John Wayne Orange County International Airport
2h 54m
2 flights a week
Allegiant
Boston, MA
BOS · Boston Logan International Airport
2h 48m
A couple of flights a week
Allegiant, Delta
Portland, OR
PDX · Portland International Airport
2h 59m
A couple of flights a week
Allegiant
SeasonalNonstops out of PDX →Jacksonville, FL
JAX · Jacksonville International Airport
2h 17m
A couple of flights a week
Allegiant
SeasonalNonstops out of JAX →Newark, NJ
EWR · Newark Liberty International Airport
2h 27m
A couple of flights a week
Allegiant
Fort Myers, FL
RSW · Southwest Florida International Airport
2h 54m
A couple of flights a week
Allegiant
SeasonalNonstops out of RSW →Sarasota, FL
SRQ · Sarasota Bradenton International Airport
2h 42m
A couple of flights a week
San Diego, CA
SAN · San Diego International Airport
2h 58m
A couple of flights a week
Allegiant, Delta, United
SeasonalNonstops out of SAN →Orlando, FL
MCO · Orlando International Airport
2h 50m
A couple of flights a week
Frontier, Delta, Southwest
SeasonalNonstops out of MCO →
Long weekend
3 to 5 hours2 citysMiami, FL
MIA · Miami International Airport
3h 6m
4 flights a week
Fort Lauderdale, FL
FLL · Fort Lauderdale Hollywood International Airport
3h
A couple of flights a week
Allegiant
Worth the extra days
5 hours and up0 citysNothing over five hours nonstop from here, which is normal for most Midwest airports. Hawaii and Alaska usually mean one connection.
Flip it: where can you fly nonstop from DSM? →
Nonstop route data from the U.S. Department of Transportation (BTS T-100), covering 2025-06..2026-05, last updated 2026-09-02. Domestic routes only. Airlines change schedules, so an advisor confirms before you book.
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