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DSM · Midwest

Nonstop from Des Moines, IA

We have partial nonstop coverage for Des Moines. What's below is verified, but it is not the full picture, so treat it as a starting point rather than a complete list. An advisor can confirm what actually flies from DSM.

35 of 35 nonstop routes

Leave after work

Under 2 hours13 destinations

  • Chicago, IL

    ORD · Chicago O'Hare International Airport

    54m

    Many flights a day

    United, American

    Regional partners: SkyWest, Republic

    Who else flies to ORD →

  • Denver, CO

    DEN · Denver International Airport

    1h 32m

    Many flights a day

    United, Southwest, Frontier

    Regional partners: SkyWest

    Who else flies to DEN →

  • Dallas-Fort Worth, TX

    DFW · Dallas Fort Worth International Airport

    1h 33m

    About 4 flights a day

    American

    Who else flies to DFW →

  • Atlanta, GA

    ATL · Hartsfield Jackson Atlanta International Airport

    1h 38m

    About 3 flights a day

    Delta

    Who else flies to ATL →

  • Minneapolis, MN

    MSP · Minneapolis–Saint Paul International Airport / Wold–Chamberlain Field

    45m

    About 3 flights a day

    Delta

    Regional partners: SkyWest

    Who else flies to MSP →

  • Detroit, MI

    DTW · Detroit Metropolitan Wayne County Airport

    1h 16m

    About 3 flights a day

    Delta

    Who else flies to DTW →

  • Charlotte, NC

    CLT · Charlotte Douglas International Airport

    1h 47m

    About 2 flights a day

    American

    Who else flies to CLT →

  • Washington, DC

    DCA · Ronald Reagan Washington National Airport

    1h 56m

    About one a day

    American

    Regional partners: Republic

    Who else flies to DCA →

  • St Louis, MO

    STL · St. Louis Lambert International Airport

    42m

    About one a day

    Southwest

    Who else flies to STL →

  • Chicago, IL

    MDW · Chicago Midway International Airport

    52m

    About one a day

    Southwest

    SeasonalWho else flies to MDW →
  • Nashville, TN

    Nashville, TN

    BNA · Nashville International Airport

    1h 14m

    3 flights a week

    Allegiant

    Photo: Brice Cooper / Unsplash

    Who else flies to BNA →

  • Austin, TX

    AUS · Austin Bergstrom International Airport

    1h 53m

    2 flights a week

    Allegiant

    Who else flies to AUS →

  • Valparaiso, FL

    VPS · Destin-Fort Walton Beach Airport

    1h 55m

    A couple of flights a week

    Allegiant

    SeasonalWho else flies to VPS →

Easy weekend

2 to 3 hours18 destinations

Long weekend

3 to 5 hours4 destinations

  • Los Angeles, CA

    LAX · Los Angeles International Airport

    3h 28m

    6 flights a week

    Regional partners: SkyWest

    Who else flies to LAX →

  • Portland, OR

    PDX · Portland International Airport

    3h 16m

    2 flights a week

    Allegiant

    SeasonalWho else flies to PDX →

  • Santa Ana, CA

    SNA · John Wayne Orange County International Airport

    3h 17m

    2 flights a week

    Allegiant

    Who else flies to SNA →

  • San Diego, CA

    SAN · San Diego International Airport

    3h 10m

    A couple of flights a week

    Allegiant, Delta

    SeasonalWho else flies to SAN →

Worth the extra days

5 hours and up0 destinations

Nothing over five hours nonstop from here, which is normal for most Midwest airports. Hawaii and Alaska usually mean one connection.

Nothing over five hours flies nonstop from DSM. That's normal for a lot of the country. Hawaii, Alaska, and Europe typically mean one connection, and an advisor picks the one least likely to cost you a day.

Flip it: who flies nonstop into DSM →

Nonstop route data from the U.S. Department of Transportation (BTS T-100), covering 2025-06..2026-05, last updated 2026-09-02. Domestic routes only. Airlines change schedules, so an advisor confirms before you book.

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